A few of the more common disorders are mentioned here. Such synapses are tagged by classical components of the complement cascade and subsequently removed by microglia through complement receptor 3 signaling 22 For example, the cognitive deficits encountered in some epileptic patients are likely due, in part, to neurodegeneration accompanying some forms of epilepsy.
Some people will have at least one seizure in their life, but to be considered an Epileptic a person must have had over two seizures. Another hemispheric syndrome, Sturge—Weber syndrome SWS; encephalotrigeminal angiomatosisconsists of a hemispheric vascular malformation, leading to intractable epilepsy and hemiparesis.
Attacks may be preceded by warning presyncopal signs, such as lightheadedness, blurred vision, pallor, nausea, or diaphoresis.
The key to the diagnosis is a family history of newborn or infantile seizures that resolved. In metabolic disorders, seizures are typically accompanied by other abnormalities, such as developmental delay, unexplained vomiting, or coma.
Disease modification, by contrast, is designed to slow progression, alleviate symptoms of epilepsy, or convert medically intractable epilepsy to drug-responsive epilepsy see the sidebar entitled Disease Modification Versus Symptomatic Intervention. Apical and basilar dendrites appear to respond differently to seizures.